ISMRM Workshops: Learn, Share Research & Network

ISMRM Workshop on

MRI of Neuromodulation:

Target Engagement, Neural Mechanism & Biomarker Development

17-19 October 2022

Ruth Kirschstein Auditorium, NIH Building 45
Bethesda, MD, USA

Thank you for a great workshop!

Presentation recordings are available in the program below.

attendees group photo

Organizers

Co-Chairs:
Danny JJ Wang, Ph.D.
Yihong Yang, Ph.D.

Registration & Travel

Registration is Closed

Travel & Nearby Housing Information

Sustainability

ISMRM Sustainability Initiatives

Supporters & Declarations

Magnetic Resonance in Medicine virtual issue on
MRI of Neuromodulation

For Attendees

Program Options:
Scroll Down | Open Separately | Download

Guidelines for Presenters & Posters

Funding for the ISMRM workshop on MRI of Neuromodulation was made possible (in part) from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Overview & Program

Workshop Overview

During recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS), as well as alternative methods using optical and ultrasonic modulations, have become an important means to study how complex neural circuits interact in the brain, to manipulate human cognition, and to treat brain disorders. Magnetic resonance imaging (MRI) can now be performed either concurrently with or pre- and post-these neuromodulation techniques to visualize their effects on the human brain, to understand the neurophysiological mechanism, and to improve their efficacy. The proposed workshop will bring together a diverse group of scientists and clinicians as well as industry partners who are interested in developing and applying advanced MRI techniques to visualize, understand, and quantify neuromodulation effects on the human brain. This workshop will be the first of its kind on the topic of MRI in neuromodulation in ISMRM history and will integrate presentations with ample discussion periods covering advances in various MRI techniques for neuromodulation (electromagnetic field mapping, functional connectivity, arterial spin labeled perfusion and permeability, temperature and acoustic radiation force imaging, etc.), preclinical animal models and cellular-level mechanisms of neuromodulation, and safety issues related to MRI with neuromodulation devices. Existing and emerging clinical applications for MRI in neuromodulation and biomarker development will be discussed between academic and industry partners.

Target Audience:

MRI scientists interested in developing novel methods for in-vivo imaging of neuromodulation effects on human brain using MRI; neuroscientists, neurologists, psychiatrists, and neurosurgeons interested in the application of in-vivo imaging of neuromodulation effects on human brain using MRI; and manufacturers of MRI and/or neuromodulation devices interested in latest advances of MRI in neuromodulation.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Explain the state-of-the-art and latest developments of concurrent MRI and neuromodulation techniques including tDCS, TMS, DBS, and emerging optical and ultrasonic modulations;
  • Define the biophysical and neurophysiological parameters that can be measured by MRI of neuromodulation;
  • Recognize the potentials and challenges of in-vivo MRI mapping of neuromodulation; and
  • Identify the suitable clinical applications and associated barriers need to be overcome for the translation ofMRI in neuromodulation.

Program

Videos, abstracts & syllabi linked below are available to registered attendees only.

  • Username: Your Member ID Number
  • Password: Your last name; case-Sensitive, no spaces, no special characters or diacritical marks

Note: all times below are shown first in EDT followed by the equivalent in your local time zone.

Day 1 - Monday, 17 October 2022 (5.5 CME Available)

Registration & Speaker Upload Available

Breakfast

Welcome Address & Remarks

Organizing Committee & Local Hosts

Session 1: MRI for Neurophysiological Mechanism of Neuromodulation

Moderators: Wynn Legon, Ph.D. & Yihong Yang, Ph.D.

Toward a Better Understanding of fMRI Signals Using Neuromodulation & Recording

Yen-Yu Ian Shih, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC, USA

Focal Transcranial Magnetic Stimulation(TMS): Translation & Back Translation

Hanbing Lu, Ph.D.
National Institute on Drug Abuse
Baltimore, MD, USA

Mechanism of Transcranial Focused US
⨯ Video Permission Withheld

Jan Kubanek, Ph.D.
University of Utah
Salt Lake City, UT, USA

Break & Speaker Upload Available

Keynote Speaker

Sarah Lisanby, M.D.
National Institute of Mental Health-NIH
Bethesda, MD, USA

Session 2: MRI in TMS

Moderator: Desmond Oathes, Ph.D.

Concurrent TMS/MRI

Olivier Reynaud, Ph.D.
Fondation Campus Biotech Genève
Genève, Switzerland

MRI & TMS

Dogu Baran Aydogan, Ph.D.
University of Eastern Finland
Kuopio, Finland

Specialized Hardware for Concurrent TMS/fMRI & TMS/fMRI/EEG, Interactions Between the Systems & Safety

Lucia I. Navarro de Lara, Ph.D.
Harvard Medical School
Boston, MA, USA

Proffered Papers - Oral Session

Twisted-Pair Receiver Coils for a Combined TMS/EEG/fMRI System

Julian Maravilla, B.Sc.
University of California, Berkeley
Berkeley, CA, USA

MRI Guided Targeting & Interpretation of TMS Assessments in the Lesioned Motor Network: A Case Report in Chronic Stroke

Lisa Krishnamurthy, Ph.D.
Atlanta Veterans Affairs Medical Center
Stone Mountain, GA, USA

Molecular Mechanisms Underlying Disrupted Brain Circuits: Multimodal Neuroimaging & Brain Stimulation Approaches

Fei Du, Ph.D.
Harvard Medical School
Boston, MA, USA

Group Photo
Lunch & Speaker Upload Available

Session 3: Emerging MRI in Optical & Ultrasonic Neuromodulation (rs-fMRI & Temperature & Acoustic Radiation Force Imaging of Optical & US Modulation)

Moderator: Bastien Guerin, Ph.D. & Jan Kubanek, Ph.D.

MRI-Guided Transcranial Focused US in Addiction & Pain

Wynn Legon, Ph.D.
Fralin Biomedical Research Institute at VTC
Roanoke, VA, USA

MRI of Near-Infrared Optical Modulation

Jacek P. Dmochowski, Ph.D.
The City College of New York
New York, NY, USA

MR-Based Verification of Transcranial Ultrasound Simulation Targeting with MR-ARFI &/or MR-Bone Imaging-Based Simulation

Kim Butts Pauly, Ph.D.
Stanford University
Stanford, CA, USA

Proffered Papers - Oral Session

MRI-Guided Transcranial Focused Ultrasound for Anesthetic Delivery in the Brain

Harriet Lea-Banks, D.Phil
Sunnybrook Research Institute
Toronto, ON, Canada

Low-Intensity Focused Ultrasound to the Left Human Dorsal Anterior Insula Alters Salience Network BOLD Signals During Resting & Pain Evoked States in an Intensity Dependent Fashion.

Andrew Strohman, M.Ph.
Fralin Biomedical Research Institute at VTC
Roanoke, VA, USA

An Implantable Optoelectronic Neurostimulator Designed for Safe Full Body MRI & Active Stimulation During MRI/fMRI.

Aurore Nieuwenhuys, M.Sc.
Synergia Medical
Mont-Saint-Guibert, Belgium

Break & Speaker Upload Available

Session 4: Oral Presentations of Abstracts

Moderators: Dogu Baran Aydogen, Ph.D., & Lysianne Beynel, Ph.D.

Optimization of a Deep Learning Strategy for Estimation of Cortical Porosity Map from MRI T1-Weighted Images

Matthieu Dagommer, M.Sc.
École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris)
Paris, France

Engagement of Deep Brain Network as a Predictor Biomarker for Clinical Response to TMS

Noreen Bukhari-Parlakturk, M.D., Ph.D.
Duke University School of Medicine
Durham, NC, USA

Towards the Validation of a Biomarker in the Diagnosis of Periodic Catatonia

Clément de Crespin de Billy, Ph.D.
Centre Hospitalier Universitaire de Strasbourg
Strasbourg, France

Personalizing Targeting in rTMS Using ASL in Depression

Ludovic Dormegny-Jeanjean, M.D.
University Hospital of Strasbourg
Strasbourg, France

Accurate Electric Field Modeling by Self Supervised Deep Learning for Fast Optimization of TMS Coil Placement

Hongming Li, Ph.D.
University of Pennsylvania
Philadelphia, PA, USA

Adjourn

Day 2 - Tuesday, 18 October 2022 (5.5 CME Available)

Registration & Speaker Upload Available
Breakfast

Session 5: MRI in Transcranial Electrical Stimulation (TES)

Moderators: Silvina G. Horovitz, Ph.D., & Yu (Andy) Huang, Ph.D.

MR Current Density Imaging (MRCDI)
⨯ Video Permission Withheld

Axel Thielscher, Ph.D.
Technical University of Denmark & Danish Research Centre for Magnetic Resonance
Copenhagen, Denmar

Current Mapping for tDCS/tACS
Presented via recording

Rosalind Sadleir, Ph.D.
Arizona State University
Tempe, AZ, USA

Magnetic Field Mapping, rs-fMRI & ASL for tDCS

Danny JJ. Wang, Ph.D., M.Sc.
University of Southern California
Los Angeles, CA, USA

How to Integrate tES with fMRI: Quality Standards, Challenges & Hopes

Hamed Ekhtiari, M.D., Ph.D.
Laureate Institute for Brain Research
Tulsa, OK, USA

Proffered Papers - Oral Session

Perivascular Space Morphological Changes in Response to Transcranial Direct Current Stimulation

Andrew Minager
Harvard Medical School
Boston, MA, USA

Modulation Effects of Transcranial Direct Current Stimulation on the Dorsal Attention & Frontal Parietal Networks & Its Association with the Placebo Effect

Valeria Sacca, B.Sc., M.Sc., Ph.D.
Harvard Medical School
Boston, MA, USA

Break & Speaker Upload Available

Session 6: MRI in DBS

Moderators: Elizabeth Ankudowich, Ph.D. & Sayim Gokyar, Ph.D.

Concurrent MRI & DBS in PD

Alexandre Boutet
University of Toronto
Toronto, ON, CA

Concurrent MRI & DBS (Technical Basic, Safety for Real Time Active DBS)

Ken Sakaie, Ph.D.
The Cleveland Clinic
Cleveland, OH, USA

DBS Targets for Neurologic Disorders (Epilepsy, Real-Time)

Erik H. Middlebrooks, M.D.
Mayo Clinic
Jacksonville, FL, USA

Proffered Paper - Oral Session

The MRDust: An Implantable Neural Interface with Data Communication via MRI

Biqi Zhao, B.Sc.
University of California, Berkeley
Berkeley, CA, USA

Lunch & Speaker Upload Available

Session 7: Modeling & Safety Issues of MRI in Neuromodulation

Moderator: Lucia I. Navarro de Lara, Ph.D.

ROAST- An Open-Source Platform for Modeling Transcranial Electrical Stimulation & its Validation

Yu (Andy) Huang, Ph.D.
Memorial Sloan Kettering Cancer Center
New York, NY, USA

Modeling of TMS

Zhi-De Deng , Ph.D.
National Institute of Mental Health
Bethesda, MD, USA

SimNIMS

Oula Puonti
DRCMR & Technical University of Denmark
Kongens Lyngby, Denmark

MRI Safety Issues for Neuromodulation Systems
Presented via recording
⨯ Video Permission Withheld

Frank G. Shellock, Ph.D.
USC Stevens Neuroimaging & Informatics Institute
Keck School of Medicine, University of Southern California
Los Angeles, CA, USA

Proffered Papers - Oral Session

Feasibility of a Simplified Virtual Human Anatomy for Determining RF-Induced Heating of Active Implantable Medical Devices

Grant Baker, M.Sc.
MED Institute, Inc.
West Lafayette, IN, USA

CNN-Based RF Safety Analysis of Passive Neuromodulation Implants for Parallel Transmission Systems at 7T

Sayim Gokyar, Ph.D.
University of Southern California
Los Angeles, CA, USA

Break & Speaker Upload Available

Session 8: Oral Presentations of Abstracts

Moderators: Olivier Reynaud, Ph.D. & A. Duke Shereen, Ph.D.

A Preliminary Meta-Analysis of the Effect of Repetitive TMS on Brain Neurometabolites Measured Using Proton Magnetic Resonance Spectroscopy

Maggie Pecsok, A.B.
University of Pennsylvania
Philadelphia, PA, USA

Augmented Reality Visualization of Transcranial Magnetic Stimulation with 3DSlicer & WebXR

Loraine Franke, M.Sc.
University of Massachusetts, Boston
Boston, MA, USA

Enhancing the Efficiency of Focal TMS Coils with Magnetic Cores

Hieu Nguyen, Ph.D.
National Institute on Drug Abuse
Baltimore, MD, USA

High-Density Theta Burst Paradigm Augments the After Effect of Transcranial Magnetic Stimulation in Rodents

Charlotte Qiong Li, M.Sc.
National Institute on Drug Abuse
Baltimore, MD, USA

Task-fMRI Identifies State-Dependent Changes in Brain Networks in WC Dystonia: Implications for Transcranial Magnetic Stimulation Targeting
⨯ Video Permission Withheld

Noreen Bukhari-Parlakturk, M.D., Ph.D.
Duke University School of Medicine
Durham, NC, USA

Adjourn

Day 3 - Wednesday, 19 October 2022 (3.5 CME Available)

Registration & Speaker Upload Available

Breakfast

Session 9: Applications of MRI Neuromodulation in Neurologic Disorders

Moderators: Alexandre Boutet, M.D., Ph.D. & Hamed Ekhtiari, M.D., Ph.D.

Combining Neuroimaging, Computational Modeling & Machine Learning to Predict tDCS Treatment Response & Customize Dosing

Adam Woods, Ph.D.
University of Florida
Gainesville, FL, USA

TMS & fMRI in Movement Disorders

Silvina G. Horovitz, Ph.D.
National Institute of Neurological Disorders & Stroke
Bethesda, MD, USA

MRI Guided fUS

Li-Min Chen, Ph.D.
Vanderbilt University Medical Center
Nashville, TN, USA

Proffered Papers - Oral Session

Concurrent Brain Stimulation & fMRI Approach to Elucidate Real-Time tDCS-Induced Modulatory Mechanisms: A Pilot Study in a Chronic Stroke Model

Venkatagiri Krishnamurthy, Ph.D.
Emory University & Atlanta Veterans Affairs Medical Center
Decatur, GA, USA

Combined E-Field Modeling & Diffusion Tractography May Identify Individualized Anatomical Targets for Antidepressant rTMS

Lipeng Ning, Ph.D.
Harvard Medical School
Boston, MA, USA

Neuroimaging Based Target Prescreening – Stage One of a Two Staged Approach for Target Selection of Non-Invasive Neuromodulation Treatment for Cocaine Use Disorder
Presented via recording
⨯ Video Permission Withheld

Tianye Zhai, Ph.D.
National Institute on Drug Abuse
Baltimore, MD, USA

Break & Speaker Upload Available

Session 10: Applications of MRI Neuromodulation in Psychiatric Disorders

Moderators: Danny JJ Wang, Ph.D., & Yihong Yang, Ph.D.

TMS/fMRi in Depression & Stress

Desmond Oathes, Ph.D.
University of Pennsylvania Perelman School of Medicine
Philadelphia, PA, USA

Toward Connectomic Deep Brain Stimulation in OCD
Presented via recording

Andreas Horn, Ph.D.
Brigham & Women's Hospital
Boston, MA, USA

Identify Neuromodulation Targets for Treatment of Substance Use Disorders

Yihong Yang, Ph.D.
National Institue on Drug Abuse
Baltimore, MD, USA

Session 11: Panel Discussion MRI Biomarker Development in Neuromodulation (Academic-Industry Partnership for Biomarker Discovery & Development) (No CME Available)

Future Directions & Open Discussion

Awards Ceremony & Closing Remarks

Adjournment & Box Lunches

🡄 Return to Future Workshops Page   |   Questions? Contact us at info@ismrm.org.

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.