ISMRM Workshops: Learn, Share Research & Network

ISMRM Workshop on

MR Imaging of X‐Nuclei (23Na & Friends):

From Controversies to Potential Clinical Applications, Part II

27-30 March 2023

The Palais du Pharo, Marseille, France

Thank you for a great workshop!

Session recordings are available in the program.

Organizers

Co-Chairs:
Lothar Schad, Ph.D.
Wafaa Zaaraoui, Ph.D.

Registration & Travel

Registration is Closed

Sustainability

ISMRM Sustainability Initiatives

Supporters & Declarations

For Attendees

Program:
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Abstracts for Posters

Livestream Archives

Guidelines for Presenters & Posters

Overview & Program

Workshop Overview

This workshop will cover the latest technical advances and potential clinical applications in X-nuclei imaging (i.e., there is more to MRI than hydrogen, 1H) using 23Na (sodium) as an example. We expect that such discussions will be informative for imaging of other X-nuclei as there are often many methodological similarities given low concentrations, complex spin dynamics when spin > 1⁄2, unique relaxation characteristics necessitating different k-Space trajectories, need for custom RF coils (usually at high field), and last but not least, issues of absolute quantification. The new biochemical information available from imaging X-nuclei linked to metabolism can address several clinical questions affecting the brain and body in a novel way. The workshop will feature invited presentations to review the technical state of the art and initiate discussion, as well as poster sessions for attendees to present their latest research. There will also be an industry discussion to promote integration of scientific advancements and "best practice" methods for clinical studies across multiple MRI vendors. Note that spectroscopy and hyperpolarization methods are excluded from this workshop as these topics are covered by other ISMRM study groups.

Target Audience

The goal is to bring together our community of experienced researchers and newcomers, both basic scientists and physicians, who are interested or engaged in developing and using non-proton X-nuclei MR imaging. Attendees are members of the X‐Nuclei Imaging Study Group, basic scientists and physicians interested or engaged in developing and using non‐proton MR imaging, and people from industries involved in X-nuclei imaging.

Educational Objectives

Upon completion of this activity, participants should be able to:

  • Recognize the controversies and challenges of imaging X-nuclei;
  • Outline choices in hardware and acquisition methods for imaging X-nuclei;
  • Discuss current and potential applications in human disease; and
  • Predict future research and clinical needs for human applications of X-nuclei MRI.

Program

Videos, abstracts & syllabi linked below are available to registered attendees only.

  • Username: Your Member ID Number
  • Password: Your last name; case-Sensitive, no spaces, no special characters or diacritical marks

Abstracts for Posters

Day 1 - Monday, 27 March 2023 (2.0 CME Available)

Registration & Speaker Upload Available

Session 1: Basic Physics & Physiology

Moderators: Lothar Schad, Ph.D. & Wafaa Zaaraoui, Ph.D.

Basic Physics: Differences Between 1H & X-Nuclei

Guillaume N. Madelin, Ph.D.
New York University Langone Medical Center
New York, NY, USA

Imaging Cellular Sodium Signals in Neurons & Astrocytes in Health & Disease
⨯ Video Permission Withheld

Christine R. Rose, Ph.D.
Heinrich-Heine-Universität Düsseldorf
Düsseldorf, Germany

Welcome Reception

Adjourn

Day 2 - Tuesday, 28 March 2023 - Physical/Technical Developments on X-Nuclei Imaging (5.0 CME Available)

Registration & Speaker Upload Available

Welcome & Introductions

Session 2: Multiquantum Imaging

Moderators: Lena V. Gast, Ph.D. & Lothar Schad, Ph.D.

Overview of Multiquantum Imaging

Simon Reichert, M.Sc.
Heidelberg University
Heidelberg, Germany

Proffered Papers - Oral Session

Spatially Resolved 39K MRSI at 7T in Skeletal Muscles for Characterization of Quadrupolar Splittings

Hedvika Haindrich Primasová, Ph.D
University of Bern
Bern, Switzerland

Prospectively Undersampled Higher Resolution 23Na Multi-Quantum Coherences MRI
⨯ Video Permission Withheld

Christian Licht, M.Sc.
Heidelberg University
Heidelberg, Germany

Break & Speaker Upload Available

Session 3: Acquisition, Reconstruction, Quantification & Contrasts

Moderators: Christian Licht, M.Sc. & Guillaume Madelin, Ph.D.

Designing k-Space for X-Nuclei Acquisitions & Reconstruction

Yasmin Blunck, Ph.D.
University of Melbourne
Parkville, VIC, Australia

Image Reconstruction Issues Related to Real Resolution, Partial Volume & B1/B0 Corrections

Lena V. Gast, Ph.D.
University Hospital Erlangen-Nuremberg
Erlangen, Germany

Quantification & Contrast Mechanisms

Robert W. Stobbe, Ph.D.
University of Alberta
Edmonton, AB, Canada

Proffered Papers - Oral Session

Sequence Comparison for Sodium MRI

Rolf Schulte, Ph.D.
GE Healthcare
München, Germany

Design of a Two-Dimensional Ultrashort Echo Time Simultaneous Multi-Slice Pulse Sequence

Jason Reich, M.Sc.
University of British Columbia
Kelowna, BC, Canada

Simulated & Measured B1 Maps in Self-Gated Respiratory-Sorted 23Na MRI Obtained with a Pulse Sequence with Alternating Excitation

Jana Felz, B.Sc.
German Cancer Research Center
Heidelberg, Germany

Lunch & Speaker Upload Available

Session 4: Hardware

Moderators: Christian Beaulieu, Ph.D. & Simon Reichert, M.Sc.

X-Nuclei Hardware Developments & Requirements

Tanja Platt, Dr. rer. nat.
German Cancer Research Center
Heidelberg, Germany

Proffered Papers - Oral Session

End-Ring Stacked Triple-Tuned Birdcage Coil for X-Nuclei Magnetic Resonance Imaging

Taewoo Nam, Ph.D. Candidate
Gachon University
Incheon, Republic of Korea

A 16-Channel Proton/Sodium Transmit/Receive Array Design for 7 Tesla Head Imaging

Menglu Wu, Ph.D. Student
King's College London
London, England, UK

Whole-Body Sodium (23Na) & Proton (1H) MRI at 7T Using a Combined 23Na Birdcage/1H Array RF Coil Set-Up

Sabine Melanie Matuschik, M.Sc.
University Hospital Erlangen
Erlangen, Germany

Break & Speaker Upload

Session 5: Other Friends Beyond 23Na

Moderators: Mounir El Mendili, Ph.D. & Armin Nagel Dr. rer. nat.

Deuterium Imaging

Jeanine J. Prompers, Ph.D.
University Medical Center Utrecht
Utrecht, The Netherlands

Proffered Papers - Oral Session

39K/23Na MRI at 7T Combined with Fat Quantification/T2 Mapping at 3T for Assessment of Ionic Balance in Patients with Hypokalemic Periodic Paralysis

Claudius Sebastian Mathy, B.Sc.
University Hospital Erlangen
Erlangen, Germany

Variability by Region & Method in Human Brain Sodium Concentrations Estimated by 23Na Magnetic Resonance Imaging: A Meta-Analysis

Ben Ridley, Ph.D.
IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, Italy

Time-Resolved Abdominal 23Na MRI During Uptake of Saline Solution at 7 Tesla

Laurent Ruck, M.Sc.
University Hospital Erlangen
Erlangen, Germany

A Quadruple-Tuned Extremity Coil Enabling Multinuclear Metabolic MR Imaging at 7 Tesla

Jiying Dai, M.Sc.
University Medical Center Utrecht
Utrecht, The Netherlands

Anatomically-Guided Sodium Image Reconstructions: Effects of Readout Length

Georg Schramm, Ph.D.
Stanford University
Stanford, CA, USA

Quantitative Brain-Regional Sodium MRI in the Healthy Human Brain: Beware of Image Artifacts

Samuel Rot, M.Sc.
University College London
London, England, UK

Adjourn

Day 3 - Wednesday, 29 March 2023 - X-Nuclei Applications (4.0 CME Available)

Registration & Speaker Upload Available

Consensus Topics: Pros & Cons

Armin Michael Nagel, Dr. rer. nat.,
Lothar Schad, Ph.D., &
Wafaa Zaaraoui, Ph.D.

Session 6: Brain Applications

Moderators: Anne Adlung, Ph.D. & Jean-Philippe Ranjeva, Ph.D.

Sodium MRI in Stroke & Brain Tumours

Christian Beaulieu, Ph.D.
University of Alberta
Edmonton, AB, Canada

Break & Speaker Upload Available

Sodium MRI in Multiple Sclerosis & Neurodegenerative Diseases

Adil Maarouf, M.D.
Aix-Marseille Université
Marseille, France

Proffered Papers - Oral Session

Quantitative High-Resolution Sodium MR Imaging can be a Clinical Reality at 3 Tesla

Keith Thulborn, M.D., Ph.D.
University of Illinois
Chicago, Illinois, USA

Study of Homeostasis Alterations of Hubs in Focal Epilepsy Using 7T Sodium & Diffusion MRI

Lucas Gauer, M.D.
Aix-Marseille University
Marseille, France

Skin Sodium Concentration Is Elevated with Aging but Relative Change Depends on Spatial Resolution of 23Na MRI

Jingxuan Zhu, B.Sc.
University of Alberta
Edmonton, AB, Canada

High Resolution Sodium Imaging of the Skin

Theodora Slater, M.Sc.
University of Nottingham
Nottingham, England, UK

Widespread Alterations in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI & Sodium MRI Study

Mohamed Mounir El Mendili, Ph.D.
Aix Marseille University & Hopital de la Timone
Marseille, France

Characterizing Thalamic Sodium Homeostasis Changes in Focal Epilepsy

Roy Haast, Ph.D.
Aix-Marseille University
Marseille, France

Poster Session
Lunch & Speaker Upload Available

Session 7: Musculoskeletal & Whole-Body Applications

Moderators: Teresa Gerhalter, Dr. rer. nat. & Jeanine J. Prompers, Ph.D.

X-Nuclei in Muscles & Cartilage

Teresa Gerhalter, Ph.D.
University Hospital Erlangen
Erlangen, Germany

Sodium MRI in Breast

Olgica Zaric, Ph.D.
Medical University of Vienna
Vienna, Austria

Break & Speaker Upload Available

Sodium MRI in Nephrology

Christoph Kopp, M.D.
Friedrich-Alexander-University, Erlangen-Nürnberg
Erlangen, Germany

Proffered Papers - Oral Session

Compressed Sensing Applied to 2D Sodium MRI of the Calf Using Half-Sinc Excitation Pulses

Rebecca Baker, Ph.D.
University College London
London, England, UK

Magnetic Resonance Imaging Assessment of Skin & Muscle Sodium in Haemodialysis

Ben Prestwich, Ph.D.
University of Nottingham
Nottingham, England, UK

Tissue Sodium Is High in Fat & Fibrosis of Human Unilateral Lymphedema

Shannon L. Taylor, B.Sc.
Vanderbilt University
Nashville, TN, USA

Adjourn

Social Event

Day 4 - Thursday, 30 March 2023 (No CME Available)

Registration & Speaker Upload Available

Session 8: Perspectives & Vendor Points of View

Moderators: Armin Nagel Dr. rer. nat & Wafaa Zaaraoui, Ph.D.

Vendor Presentations

Round Table with Vendors: State of the Art, Needs & Support

Break

General Discussion

Summary & Closing Remarks

Claudia A. Gandini Wheeler-Kingshott, Ph.D.
University College London
London, England, UK

Closing Statements, Boxed Lunches & Adjournment

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